The research activity of the Clinical and Experimental Research Center of IRCCS San Raffaele in Rome is mainly based on rehabilitation in all cardiovascular diseases with specific interest in heart failure and its causes, ischemic heart disease, and gender differences. The research group also has specific interest on the effect of cardiovascular rehabilitation on disabilities induced by heart failure and sequelae of ischemic heart disease with interest on frailty and innovative drug therapies. The Clinical and Experimental Research Center studies innovative rehabilitation mechanisms through the use of telemedicine and telehealth combined with robotics and artificial intelligence.