Line 1 – Models and preclinical factors determining the effectiveness of rehabilitation

Descrizione

  • Cellular, molecular, and genetic determinants of the rehabilitative response to physical training in models reproducing neurodegenerative, neuromotor, cerebrovascular, metabolic, and chronic degenerative diseases of the cardiovascular and respiratory systems and in pain.
  • Preclinical determinants in the study of rehabilitation pathways of multimorbid patients.
  • Identification and evaluation of predictive biomarkers for rehabilitation treatment.

Descrizione

  • Cellular, molecular, and genetic determinants of the rehabilitative response to physical training in models reproducing neurodegenerative, neuromotor, cerebrovascular, metabolic, and chronic degenerative diseases of the cardiovascular and respiratory systems and in pain.
  • Preclinical determinants in the study of rehabilitation pathways of multimorbid patients.
  • Identification and evaluation of predictive biomarkers for rehabilitation treatment.

Background/Background

Rehabilitation medicine needs to overcome the empiricism that has characterized its actions in the past to equip itself with solid measurable preclinical evidence.

The study of preclinical pathogenetic mechanisms allows the identification of mechanisms of functional recovery, enabling a personalized and truly translational pathway.

The creation of solid models that enable the analysis of the healthy and the disabled subject is supportive of the objective assessment of the clinical state, the understanding of the phenomena of functional recovery, and the optimization of the personalization of the rehabilitation-therapeutic approach.

Genotype-phenotype-environment integration is the basis of future rehabilitation.

Background/Background

Rehabilitation medicine needs to overcome the empiricism that has characterized its actions in the past to equip itself with solid measurable preclinical evidence.

The study of preclinical pathogenetic mechanisms allows the identification of mechanisms of functional recovery, enabling a personalized and truly translational pathway.

The creation of solid models that enable the analysis of the healthy and the disabled subject is supportive of the objective assessment of the clinical state, the understanding of the phenomena of functional recovery, and the optimization of the personalization of the rehabilitation-therapeutic approach.

Genotype-phenotype-environment integration is the basis of future rehabilitation.

Rational

Identifying the etiopathogenetic mechanisms underlying disabling diseases will enable the development of innovative therapeutic strategies.

In-depth knowledge of the pathogenetic mechanisms of chronic degenerative diseases, with the identification of endogenous molecules released by damaged tissues, can be a useful tool for the discovery of biomarkers useful for monitoring disease progression and the effectiveness of rehabilitation.

Knowledge of early events that determine the progression of disabling diseases is critical to identifying risk markers and novel determinants of out-come.

Therefore, it is important to be able to: identify mutual alterations in bioenergetic metabolism and suggest nutritional/pharmacological and rehabilitative approaches.

Rational

Identifying the etiopathogenetic mechanisms underlying disabling diseases will enable the development of innovative therapeutic strategies.

In-depth knowledge of the pathogenetic mechanisms of chronic degenerative diseases, with the identification of endogenous molecules released by damaged tissues, can be a useful tool for the discovery of biomarkers useful for monitoring disease progression and the effectiveness of rehabilitation.

Knowledge of early events that determine the progression of disabling diseases is critical to identifying risk markers and novel determinants of out-come.

Therefore, it is important to be able to: identify mutual alterations in bioenergetic metabolism and suggest nutritional/pharmacological and rehabilitative approaches.

Global goals

Identification/Realization of models reproducing cellular, molecular, genetic, nutritional, and microbial determinants in the rehabilitation response in neurodegenerative, neuromotor, cerebrovascular, orthopedic, cardiovascular, respiratory diseases, and chronic pain. Identification of biomarkers to predict the effectiveness of this response.

Global goals

Identification/Realization of models reproducing cellular, molecular, genetic, nutritional, and microbial determinants in the rehabilitation response in neurodegenerative, neuromotor, cerebrovascular, orthopedic, cardiovascular, respiratory diseases, and chronic pain. Identification of biomarkers to predict the effectiveness of this response.

Expected Results.

  • Identification of novel markers of diagnosis and translational progression for disabling diseases.
  • Identification of new preclinical models specific to nutritional and pharmacological aspects for rehabilitation in disabling diseases.
  • Identification of integrated genotype-phenotype-environment patterns favoring/disfavoring rehabilitation outcome.

Expected Results.

  • Identification of novel markers of diagnosis and translational progression for disabling diseases.
  • Identification of new preclinical models specific to nutritional and pharmacological aspects for rehabilitation in disabling diseases.
  • Identification of integrated genotype-phenotype-environment patterns favoring/disfavoring rehabilitation outcome.

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