• Clinical study of the efficacy of rehabilitative exercise, technological, pharmacological, and nutritional principals in functional recovery of disabling diseases.
• Evaluation of multimorbidity in achieving rehabilitation outcome.
• Study and refinement of integrated biomarkers for the evaluation of efficacy and prediction of recovery for optimizing the personalization of rehabilitation treatment in patients with disabling diseases/conditions, such as stroke, neurodegenerative diseases, musculoskeletal diseases, heart failure, cardio-operated, or orthopedic patients.
• Multi-domain clinical, electrophysiological, biomechanical, central and peripheral neural correlates, psychological and functional study.
• Experimenting with new pathology-specific therapeutic rehabilitation pathways.

In the bio-psycho-social vision of a modern rehabilitation, it becomes essential to take comprehensive care of the patient with disabilities in order to achieve the best possible quality of life while also promoting proper reintegration into working and social life.

Rehabilitation activities cannot be separated from knowledge of the pathogenetic mechanisms of disabling diseases. With this in mind, it becomes necessary to study the mechanisms of injury and post-injury recovery. Special attention should be paid to the study of pathology clusters (complexity) that can determine the rehabilitation outcome. New epidemiological and population cohort studies toward disabling diseases are also needed in order to implement an effective prevention policy.

Constant updating of procedures and techniques implemented in rehabilitation should also be ensured.

Intensive rehabilitation treatment determines the extent and quality of recovery of the person with the disabling condition, especially when the rehabilitation pathway is implemented as early as possible from the acute event. In the context of disabling neurological disorders for example, neuroplasticity is strongly stimulated by effective intensive rehabilitation treatment. Similarly in the cardiorespiratory field, rehabilitative activity enables good recovery of function. Modern rehabilitative treatments must therefore be carried out through the study and analysis of the Patient’s real chances of recovery (individual rehabilitation plan), which are derived from an effective biopsychosocial intake of the individual. Hence the need to conduct a comprehensive analysis of the Patient’s health status, identifying and properly managing integrated and related pathologies.

• To identify multivariable factors and indices that influence the response to rehabilitation treatment, recovery, and quality of life of patients with disabling conditions.
• To test and evaluate new rehabilitative, pharmacological, nutraceutical, and behavioral treatments to improve functional recovery in specific populations.

• Development of new and more effective clinical and technological evaluation systems.
• Identification of predictors of recovery that can facilitate and make the rehabilitation project more targeted.
• New procedures for assessing functional gain, predicting treatment response, and improving and personalizing the treatment approach.
• Implementation of integrated models of interdisciplinary and multifactorial treatment of disabling conditions in the Complex Patient.

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