• Implementation of new pathology-specific rehabilitation pathways in new organizational models for the delivery of activities, including to ensure continuity of care in the territory in patients with disabling diseases and to propose new processes for early assessment of functional decline.
• Implementation of programs dedicated to improving the self-monitoring ability of patients (with neuromotor and cognitive deficits) through the use of new technologies and systems that facilitate their learning also supported by Artificial Intelligence technologies.
• (In)training of patients and caregivers, for creation of patient empowerment and quality of life assessment.
• Implementation of Clinical Governance of Rehabilitation through outcome monitoring.

An aging population, increased incidence of chronic diseases are causing new health needs to emerge that require personalized care and treatment pathways. In this scenario, the validation of innovative treatments (e.g., telerehabilitation) can be an effective and efficient response. Chronic noncommunicable diseases are multifactorial and caused by complex gene-environment interactions acting throughout the life course. The holistic approach to rehabilitation predisposes for the integration of preclinical, clinical, and environmental data thus facilitating the understanding of disease mechanisms and improving diagnosis, treatment, and prognosis.

New information and communication technologies have proven to be the most promising strategic tool for ensuring continuity of clinical management and preservation of well-being.

Rehabilitation consists of a comprehensive, multidisciplinary intervention based on evidence of benefit to patients based on objective, quantifiable parameters of effectiveness, aimed at reducing symptoms, optimizing functional status, increasing participation, and reducing consumption of health care resources through stabilizing or ameliorating disease. The literature has highlighted the usefulness of intervention with telerehabilitation, demonstrating its validity in both economic and welfare terms. Currently, a large number of telerehabilitation platforms have been developed that require new scientific evidence.

Information and communication technologies, in concert with the new possibilities given by pervasive sensing systems, Internet of Things, Environmental Intelligence, Machine Learning, and Ubiqua Computation, pose new challenges in the implementation of complex integrated systems for the management and treatment of patients.

• Implementation of new PDTAs with telerehabilitation pathways and innovative devices for self-monitoring
• Innovative functional neuroimaging techniques.
• New technologies such as sensor networks, advanced algorithms, and applied robotics to restore sensory or motor function.
• Optimizing access to modern high-cost rehabilitation procedures through the application of HTA criteria.

• Activation of home-based rehabilitation programs otherwise not permitted in other organizational modality.
• Defining new rehabilitation pathways that are scientifically certain, socially useful and economically sustainable.
• Implementation, development and validation of advanced rehabilitation systems, new algorithms for treatment delivery, assistive technology to facilitate patient-therapist contact.

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