MNESYS Research Project

The Notice

PUBLIC NOTICE FOR TENDERS AND FOLLOW-UP FOR THE GRANTING OF 11 RESEARCH PROJECT CONTRACTS FOR YOUNG RESEARCHERS/RESearchers FOR THE RESEARCH PROJECT TITLE: “A multiscale integrated approach to the study of the nervous system in health and disease” – MNESYS.

 

The project falls under the Public Notice for the submission of project proposals for “Partnerships extended to universities, research centers, action for the funding of basic research projects” to be funded under the PNRR Mission 4, “Education and Research” – Component 2, “From Research to Enterprise” – Investment Line 1.3, “Partnerships extended to universities, research centers, companies for the funding of basic research projects,” funded by the European Union – NextGenerationEU. Research activities take place for the duration of the project at IRCCS San Raffaele facilities.

The detail

IRCCS San Raffaele Roma srl is committed to complying with the specific dictates of the NRP, such as:

– the notices of recruitment of new personnel include appropriate clauses directed to the inclusion, as additional reward requirements of the offer, of criteria oriented to promote the employment of women, in accordance with the provisions of Article 47 “Equal opportunities, generational and gender, in PNRR and PNC public contracts” of Decree-Law No. 31 May 2021, no. 77 converted into law July 29, 2021, no. 108;

– “Do No Significant Harm (DNSH)”: the principle of “do no significant harm” according to which no measure funded by the notices shall cause harm to environmental objectives, consistent with Article 17 of Regulation (EU) 2020/852;

– “Open science”: approach to the scientific process based on cooperation and new ways to disseminate knowledge, improve accessibility and reusability of research results through the use of digital technologies and new collaboration tools. Open science is a priority policy of the European Commission and the benchmark working method in public research and innovation funding;

– “FAIR Data Principles”: a set of principles, guidelines, and best practices designed to ensure that research data are Findable, Accessible, Interoperable, and Re-usable, subject to ethical, commercial, and confidentiality constraints and the principle of “as open as possible and closed only as much as necessary.”

 

As required by the Guidelines of the Research Project under the PNRR Call titled: MNESYS“A multiscale integrated approach to the study of the nervous system in health and disease,” which involves IRCCS San Raffaele in the specific activities coordinated under the following Spokes:

– Spoke 2 Neuronal plasticity and connectivity, Prof. Paolo Maria Rossini

– Spoke 6 Neurodegeneration, trauma and stroke, Prof. Barbara Picconi

– Spoke 7 Neuroimmunology and Neuroinflammation, Prof. Georgia Mandolesi

 

Art.1

IRCCS San Raffaele has announced public selection for the award of 11 research project contracts (co.co.co.) for the profiles below, within the Extended Partnership Project “MNESYS – A multiscale integrated approach to the study of the nervous system in health and disease” Spoke 6, funded under the PNRR MUR Program – Mission 4, Component 2, Investment 1.3 – CUP B83D22000980006. This research program will be carried out in the laboratories of the Research Center or at the Rehabilitation Presidium of IRCCS San Raffaele under the scientific supervision of the relevant managers, mentioned above.

Equal opportunity between men and women is guaranteed for access to research project contracts, pursuant to Law No. 10 of February 1991. 125. Therefore, candidates of either sex who meet the prescribed requirements are allowed to participate in the notice. In this regard under Art. 4, paragraph 3, of Law No. 125/91, it is specified that the term “candidates,” used in the text should always be understood in the sense specified above, and, therefore, referring to aspirants “of either sex.”

 

Researcher Profiles SPOKE Project 2

BIOINGEGNERS

Engineering graduate (majoring in medical engineering, electronics, computer science) with proven experience in the field of neuroengineering, particularly in applying research protocols intended for multimodal neuroimaging using advanced neurophysiological techniques (high-resolution EEG, TMS, MEG, fMRI) and interacting with data from such multimodal sources. Experience in using neuroimaging methods for neurofeedback protocols and/or brain-machine interfaces will be considered favorably.

 

BIOINFORMATICIANS

Math/Physics/Engineering/Computer Science graduate with proven experience in the field of bioinformatics, particularly in multimodal analysis of data from advanced neurophysiological techniques, such as high-resolution EEG, TMS, MEG, fMRI. Experience in the study and/or use of algorithms dedicated to the investigation of cortico-cortical connectivity and/or functional synchronization and binding know considered positively.

 

BIOSTATISTIC

Graduate student in Mathematics/Physics/Engineering/Computer Science/Statistics with proven experience in the field of biostatistics.

 

TNFP

Neurophysiopathology technician with proven experience in EEG, SEP, TMS-EEG recording protocols.

 

NEUROLOGISTS

Neurology physician with proven experience in the field of multimodal neuroimaging using advanced neurophysiological techniques (high-resolution EEG, TMS, MEG, fMRI) for functional structural analysis, preferably for the study of brain aging and neurodegenerative diseases. Experience in the use of advanced radioisotopic neuroimaging methods (based on flow/metabolism and PET/SPECT signal) will be considered favorably.

 

NEUROPSYCHOLOGISTS

Physician specializing in neurology with proven experience in clinical neuropsychology. Experience in the delivery and analysis of behavioral test batteries and related task domains intended for the study of brain aging and neurodegenerative diseases will be valued highly.

 

BIOLOGIST

Master biologist with experience in cell culture, western blot molecular biology techniques, elisa for studying in vitro models of neurodegenerative diseases.

 

Master biologist with expertise in cell culture, immunohistochemistry and confocal immunofluorescence techniques for the study of in vitro models of neurodegenerative diseases and neuroinflammation.

 

Researcher Profiles SPOKE Project 6

LABORATORY TECHNICIAN

Laboratory Technician: experience in laboratory techniques and specifically in HPLC measurements from human biological samples.

 

Researcher Profiles SPOKE Project 7

BIOLOGIST

Two positions are available for highly motivated young postdoc/young researcher with a bachelor’s degree in biology or related degrees to conduct research in molecular biology and biochemistry applied to neuroscience in the Immunopathology Laboratory of IRCCS San Raffaele, Rome.

The research project aims to elucidate the cellular and molecular mechanisms underlying neuroinflammatory and neurotoxic processes in neurodegenerative diseases such as Multiple Sclerosis, in order to identify new biomarkers and/or therapeutic targets and to develop new pharmacological approaches based on the use of nanoparticles For an initial post-doc position, people who have done an experimental dissertation and/or with documented experience in multiple laboratory techniques applied to preclinical and clinical research, in particular molecular biology (real time PCR analysis for mRNA and microRNA) and biochemistry (Western blot; ELISA immunoassay, Luminex technology) . In addition, since murine models are to be used, experience or at least willingness to work with animal models is required.

For a second post-doc position, expertise and background in the study of interactions between cells of the brain compartment including neurons, astrocytes, glia with natural (exosomes) and synthetic (liposomes and other nanoparticles) nanovesicles is preferred. Expertise in studying the functioning of the blood-brain barrier and its crossing by cells and nanostructures.

Art. 2

Winners will be insured against occupational accidents in accordance with the provisions contained in Presidential Decree No. 1124 of June 30, 1965, with INAIL, without prejudice to the provisions of Law No. 1659 of December 29, 1941.

 

Art.3

Citizens of the European Union residing there who have obtained the required degree by the start of the contracts are eligible to participate in the competition.

However, tenured university professors or those belonging to personnel categories equated with tenured university professors and university researchers may not participate.

 

Art. 4

Applications for admission to the Call, written on plain paper and accompanied by the assessable qualifications, must be submitted electronically to IRCCS San Raffaele by 6 p.m. on September 15, 2023.

The application in electronic format should be sent to the following addresses: bandi.mnesys@sanraffaele.it and sara.ilari@sanraffaele.it and have in the subject line the words “MNESYS Extended Partnership Project Scholarship Announcement.” IRCCS San Raffaele assumes no responsibility for any mishaps in the delivery, which must arrive within the established deadlines of the Notice.

 

Applicants should clearly and precisely state in the application:

(a) surname and first name, place and date of birth;

(b) residence, social security number;

(c) the e-mail address and telephone numbers to which he/she would like communications regarding the competition to be sent;

(d) the educational qualification(s) held, in relation to what is required for the individual fellowship, specifying the date and place of its attainment and the mark given in the final examination;

(e) foreign languages known and the degree of proficiency;

(f) to be a European citizen;

(g) they have no criminal convictions, specifying, if not, which convictions they have;

(h) that he/she is not an employee of other public or private entities, if he/she is a recipient of other scholarships and similar emoluments, and if so, which ones.

 

At the bottom of the application, the applicant must sign the application in full and in a clear and interpretable manner.

 

The following documents must be attached to the application:

1) Self-certification regarding possession of the required degree(s), or relevant certificate(s) on unstamped paper issued by the competent University;

2) The curriculum vitae et studiorum;

3) Dissertation paper and/or published articles;

4) List of all documents and titles submitted.

 

All documentation should be attached to IRCCS San Raffaele along with the application.

In fact, titles and documents submitted after the deadline referred to in Paragraph I of this Article will not be taken into account, nor will applications that, on the date of expiration of this deadline, were lacking the prescribed basic documentation; nor will it be permitted, finally, after the deadline itself has expired, to replace titles and documents already submitted, even if they are substituting typescripts or drafts for the corresponding published works.

Any discrepancy between the submitted application and documentation and the documents required by the notice will be grounds for exclusion from the competition.

 

Art. 5

Candidates will be judged by a committee, appointed by the President and chaired by the Scientific Director of IRCCS San Raffaele.

Candidates may be called by the Commission for an interview. In such a case, written notice transmitted by e-mail of at least 7 days will be given to them.

For the purpose of judging merit, the Commission will take into account the evaluation of the qualifications listed in items 1-4 of Article 4 submitted by the candidate, as well as the result of the interview, if any, evaluating both the aptitude to carry out scientific research tasks in general and the preparation in the specific field of studies required for the performance of the fellowship.

The merit judgment of the Commission is final.

 

Art. 6

Upon completion of its work, the Commission will draw up a report ranking the candidates. Any ex aequo votes within the ranking list are excluded.

 

Art. 7

Contracts that, according to the provisions of Art. 6 of the Regulations for the Awarding of Contracts to Research Projects, remain available due to lack, waiver or forfeiture of the winners, may be awarded (within the maximum limit of three months from the start of the contract) to the successful candidates in the order of the ranking list; in this case, the total amount of the research contract will be reduced in proportion to the remaining time of fruition.

 

Art. 8

Based on the rankings of the winners mentioned in Article 5 above, the co.co.co. contract. for research will be awarded by order of the President of IRCCS San Raffaele.

Within a peremptory period of 7 days from the date of receipt of the notice of formal award of the co.co.co. contract, the assignees must send IRCCS San Raffaele a declaration of acceptance, without reservation, of the co.co.co. contract itself, under the conditions communicated to them.

Winners who do not comply with the requirements within the deadline will be considered to have forfeited the co.co.co. contract. for research.

Art. 9

The fellowship is for one year and may be extended by agreement between the parties, with the same duration as the research project.

From the start date of the co.co.co. contract. for research, the holder shall initiate the planned studies and research and shall, therefore, continue them regularly and uninterruptedly throughout the duration of the contract.

The grantee who after starting the planned research activity does not pursue it, without justified reason, regularly and uninterruptedly for the entire duration of the contract, or who is responsible for serious and repeated failures, or who, finally, provides evidence that he or she does not possess sufficient aptitude for research, will be declared forfeited, by reasoned decision of the Director General of IRCCS San Raffaele, from further use of the contract.

Said measure, which will be adopted upon the proposal of the Research/Project Line Manager, will be

Brought to the attention of the person concerned.

Temporary postponements and suspensions in the enjoyment of the co.co.co. contract may be justified. for research only in the event that the incumbent must be absent due to pregnancy and puerperium, illness of more than one month’s duration, or other serious reasons duly substantiated and promptly reported to IRCCS.

 

Art. 10

Payment of the scholarship will be made in monthly installments in arrears.

The first installment will be disbursed after the Research Line Manager reports that theco.co.co. contract holder. for research began the planned and agreed activities.

Art. 11

According to the provisions of the guidelines prepared for the management of the NRP project, the contractor will be asked for a monthly report on the activities carried out.

The IRCCS reserves the right, in any case, to adopt at any time, appropriate forms of ascertaining the status of ongoing research by the assignee of the co.co.co. contract. for research.

 

Art. 12

For more information, please contact the Research Office at IRCCS San Raffaele, Via di Val Cannuta no. 247, Rome Monday through Friday tel. 06-5225-2319, or 06-5225-3778, e-mail: bandi.mnesys@sanraffaele.it

 

Art. 13

Lastly, IRCCS San Raffaele reserves the right to modify, extend, suspend or revoke this notice, providing timely notice to interested parties, without, however, being obliged to communicate the reasons and without the interested parties being able to make any claims or rights whatsoever.

 

Art. 14

A copy of the notice is available at the Scientific Directorate of IRCCS San Raffaele, with hours between 12 noon and 2 p.m. Monday through Friday and is posted at www.sanraffaele.it

 

 

Rome, May 26, 2023

 

Dr. Carlo Trivelli

The Legal Representative

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