In the Laboratory of Experimental Neurophysiology directed by Professor Barbara Picconi, we study the mechanisms, synaptic, biomolecular and metabolic involved during the process of dopaminergic neurodegeneration, typical of Parkinson’s disease. In the laboratory numerous experimental models are examined, but the main goal is to put at the center of these studies, transdifferentiated neurons from iPCs of the same patients taken from a healthy or diseased donor subject and able through modern biomolecular induction techniques to transdifferentiate into mature neurons. It is also of considerable interest to study the network mechanisms in cortical, hippocampal and subcortical areas underlying motor and cognitive alterations in various degenerative diseases. The main objective of the laboratory is to investigate the pathogenetic mechanisms of Parkinson’s disease (MP) and other neurodegenerative diseases and its correlation with neuroinflammation processes. The laboratory uses electrophysiological, amperometric techniques for neurotransmitter release and confocal immunofluorescence.