Laboratory of Microbiology of Chronic-Degenerative Diseases.

Responsabile: Limongi Dolores
Staff: Checconi Paola, Ambrosi Cecilia, Prezioso Carla, Marinelli Anna Maria

The Microbiology of Chronic-Degenerative Diseases laboratory engages in basic and clinical research embracing different aspects of Microbiological Sciences ranging from the structure of the major classes of microorganisms (bacteria and viruses), to their functions and their role in the pathogenesis of infectious, inflammatory and chronic-degenerative diseases.
Research activity is mainly focused on the study of microorganism-host interactions and identification of intracellular factors involved in the control of bacterial/viral replication and inflammatory response as potential targets for innovative therapeutic strategies.
Special attention is devoted to identifying prognostic and predictive biomarkers of pathogen/mediated disease, defining cellular pathways implicated in virus-mediated oncogenic and pathogenic activity, and evaluating the evolution of antibiotic resistance in bacterial strains isolated from hospital infections.

Interessi di Ricerca

  • Study of microorganism-host interactions;
  • Identification of intracellular factors involved in the control of bacterial/viral replication and innate and adaptive inflammatory response;
  • Identification of prognostic and predictive biomarkers of pathogen-mediated diseases;
  • Identification of cellular pathways implicated in virus-mediated oncogenic and pathogenic activity;
  • Study of the mechanisms underlying the emergence and evolution of antibiotic resistance.

Pubblicazioni

1) ChecconiP, ConiC, Limongi D, BaldelliS, CiccaroneF, De AngelisM MengozziM, GhezziP, C MR, NencioniL, Palamara, AT. Influenza virus replication is affected by glutaredoxin1-mediated protein deglutathionylation FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 2023, 37(2), pp. e22729. 2) Prezioso C, Passerini S, Limongi D, Palamara AT, Moens U, Pietropaolo V COS-7 and SVGp12 Cellular Modelsto Study JCPyV Replication and MicroRNA Expression after

Le strutture