Laboratory of omics science and precision medicine

Responsabile: Romani Luigina
Staff: Russo Matteo, Garaci Enrico

Through the use of omics technologies, the Laboratory of Omics Sciences and Precision Medicine proposes the study of the microbiota (Metagenomics), its function (Transcriptomics), microbial and non-microbial metabolites (Metabolomics) as well as the host (Genomics and Immunomics) in order to develop predictive algorithms of health and disease as well as therapeutic response in the context of personalized and participatory medicine. Based on the cross-regulatory activity between the microbiota and various immunometabolic processes in the host and the resulting association between changes in microbiota composition and numerous metabolic and inflammatory states, The laboratory aims to channel big data obtained through omics-mediated technologies into a broad spectrum of cardiovascular, neurodegenerative, and metabolic diseases in order to arrive at precision medicine based on biomarkers and bioinformatics algorithms.

Interessi di Ricerca

  • Integrated study of metagenomics, metabolomics, transcriptomics, genetics and immunomics in neurodegenerative, neuromuscular, cardiovascular diseases and related rehabilitation therapy.
  • Development of appropriate computer models and tools.

Pubblicazioni

Giorgia Renga, Emilia Nunzi, Matteo Puccetti, Marina B. Bellet, Marilena Pariano, Giuseppe Pieraccini, Fiorella D’Onofrio, Ilaria Santarelli, Claudia Stincardini, Franco Aversa, Francesca Riuzzi, Maurizio Ricci, Stefano Giovagnoli, Luigina Romani and Claudio Costantini. Optimizing therapeutic outcomes of immune checkpoint blockade by a microbial tryptophan metabolite. J Immunother Cancer. 2022;10(3):e003725. IF: 12.48 Giorgia Renga, Fiorella D’Onofrio, Marilena Pariano, Roberta Galarini, Carolina Barola, Claudia Stincardini, Marina M Bellet, Helmut Ellemunter, Cornelia Lass-Flörl, Claudio Costantini, Valerio Napolioni, Allison K. Ehrlich, Cinzia Antognelli, Massimo Fini, Enrico Garaci, Emilia Nunzi and Luigina Romani. Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia. Nat Comm, upon revision. IF:17.69

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