Laboratory of Physiology and Pharmacology of Pain

Responsabile: Ilari Sara
Staff: Malafoglia Valentina, Passacatini Lucia Carmela

The activity of the Physiology and Pharmacology of Pain laboratory is focused on the study of the involvement of free radicals in algogenic reactivity, with special emphasis on the development and testing of new classes of neuroprotective and pain-relieving drugs of both synthetic and natural origin and the study of new biomarkers for the identification of acute/chronic pain.

The main goals of the laboratory are to produce robust experimental data that strengthen the early evidence on the action of free radicals in the development of acute and postoperative pain (observed in different pain models) and to identify new therapeutic approaches and new biological targets for the development of more effective and safer therapies and rehabilitation programs.

The research laboratory, over the years, has established numerous scientific collaborations both at the national level: Magna Graecia University of Catanzaro (Prof. Carolina Muscoli, Prof. Vincenzo Mollace, Prof. Filippo Familiari), the ISAL Foundation (Prof. William Raffaeli), Sapenzia University (Prof. Marco Tafani), the University of Messina (Prof. Daniela Caccamo), and at the international level: Saint Louis University(Prof. Salvemini).

Interessi di Ricerca

  • Study of cellular target proteins in acute/chronic pain using established and novel pharmacological agents (antioxidants) to alleviate oxidative stress related to ROS production.
  • Research of new biological targets for the development of effective and safe therapies and rehabilitation programs
  • Study of animal models of pain of different etiology for understanding pain and the underlying peripheral and central pathogenetic mechanisms.


Andreadi A, Muscoli S, Tajmir R, Meloni M, Muscoli C, Ilari S, Mollace V, Della Morte D, Bellia A, Di Daniele N, Tesauro M, Lauro D. RecentPharmacologicalOptions in Type 2 Diabetes and SynergicMechanism in CardiovascularDisease. Int J Mol Sci. 2023Jan13;24(2):1646. doi: 10.3390/ijms24021646. PMID: 36675160; PMCID: PMC9862607.   Garofalo C, Cristiani CM, Ilari S, Passacatini LC, Malafoglia V, Viglietto G, Maiuolo J, Oppedisano F, Palma E, Tomino C, Raffaeli W, Mollace V, Muscoli C. Fibromyalgia and IrritableBowelSyndromeInteraction: A PossibleRole for GutMicrobiota and Gut-Brain Axis. Biomedicines. 2023 Jun 13;11(6):1701. doi: 10.3390/biomedicines11061701. PMID: 37371796; PMCID: PMC10296515.   Malafoglia V, Ilari S, Gioia C, Vitiello L, Tenti M, Iannuccelli C, Cristiani CM, Garofalo C, Passacatini LC, Viglietto G, Scavalli AS, Tomino C, Mollace V, Raffaeli W, Di Franco M, Muscoli C. An ObservationalStudy on ChronicPainBiomarkers in Fibromyalgia and OsteoarthritisPatients: WhichRole for Mu OpioidReceptor’sExpression on NK Cells? Biomedicines. 2023 Mar 17;11(3):931. doi: 10.3390/biomedicines11030931. PMID: 36979910; PMCID: PMC10046119.   Bosco F, Guarnieri L, Nucera S, Scicchitano M, Ruga S, Cardamone A, Maurotti S, Russo C, Coppoletta AR, Macrì R, Bava I, Scarano F, Castagna F, Serra M, Caminiti R, Maiuolo J, Oppedisano F, Ilari S, Lauro F, Giancotti L, Muscoli C, Carresi C, Palma E, Gliozzi M, Musolino V, Mollace V. PathophysiologicalAspects of MuscleAtrophy and OsteopeniaInduced by ChronicConstrictionInjury (CCI) of the SciaticNerve in Rats. Int J Mol Sci. 2023Feb13;24(4):3765. doi: 10.3390/ijms24043765. PMID: 36835176; PMCID: PMC9962869.   Ilari S, Passacatini LC, Malafoglia V, Oppedisano F, Maiuolo J, Gliozzi M, Palma E, Tomino C, Fini M, Raffaeli W, Mollace V, Muscoli C. Tantali fibromyalgicsupplicium: Isthereanyrelief with the antidepressantemployment? A systematicreview. Pharmacol Res. 2022 Dec;186:106547. doi: 10.1016/j.phrs.2022.106547. Epub 2022 Nov 4. PMID: 36336218.   Vitiello L, Ilari S, Sansone L, Belli M, Cristina M, Marcolongo F, Tomino C, Gatta L, Mollace V, Bonassi S, Muscoli C, Russo P. Preventive MeasuresagainstPandemics from the Beginning of Civilization to Nowadays-How EverythingHasRemained the Same over the Millennia. J ClinMed. 2022Apr1;11(7):1960. doi: 10.3390/jcm11071960. PMID: 35407571; PMCID: PMC8999828.   Andreadi A, Muscoli S, Tajmir R, Meloni M, Minasi A, Muscoli C, Ilari S, Mollace V, Della Morte D, Bellia A, Campione E, Di Daniele N, Lauro D. InsulinResistance and Acne: The Role of Metforminas Alternative Therapy in Men. Pharmaceuticals (Basel). 2022Dec26;16(1):27. doi: 10.3390/ph16010027. PMID: 36678524; PMCID: PMC9862044.   Ilari S, Proietti S, Russo P, Malafoglia V, Gliozzi M, Maiuolo J, Oppedisano F, Palma E, Tomino C, Fini M, Raffaeli W, Mollace V, Bonassi S, Muscoli C. A SystematicReview and Meta-Analysis on the Role of Nutraceuticals in the Management of NeuropathicPain in In Vivo Studies. Antioxidants (Basel). 2022 Nov 28;11(12):2361. doi: 10.3390/antiox11122361. PMID: 36552569; PMCID: PMC9774415.   Vitiello L, Gatta L, Ilari S, Bonassi S, Cristina M, Ciatti F, Fini M, Proietti S, Russo P, Tomino C, Limongi D. Long Lasting Cellular Immune ResponseInduced by mRNAVaccination: Implication for PreventionStrategies. Front Immunol. 2022 Mar 10;13:836495. doi: 10.3389/fimmu.2022.836495. PMID: 35359985; PMCID: PMC8961295.   Tenti M, Raffaeli W, Malafoglia V, Paroli M, Ilari S, Muscoli C, Fraccaroli E, Bongiovanni S, Gioia C, Iannuccelli C, Di Franco M, Gremigni P. Common-sense model of self-regulation to cluster fibromyalgiapatients: results from a cross-sectionalstudy in Italy. ClinExpRheumatol. 2022 Jun;40(6):1175-1182. doi: 10.55563/clinexprheumatol/cd7fa1. Epub 2022 Jun 8. PMID: 35699086.   Ilari S, Russo P, Proietti S, Vitiello L, Muscoli C, Tomino C, Milic M, Bonassi S. DNA damage in dementia: Evidence from patientsaffected by severe ChronicObstructivePulmonaryDisease (COPD) and meta-analysis of mostrecentliterature. Mutat Res GenetToxicolEnvironMutagen. 2022 Jun;878:503499. doi: 10.1016/j.mrgentox.2022.503499. Epub 2022 May 6. PMID: 35649670.

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