Laboratory of Synaptic Immunopathology

Responsabile: Mandolesi Georgia
Staff: Mechelli Rosella, Musella Alessandra, Fresegna Diego

The Synaptic Immunopathology Laboratory has two rooms at IRCCS San Raffaele Rome Labs 40. The laboratory is equipped to conduct research in the areas of cell biology (microglia; lymphocytes), molecular biology (PCR; Digital), and to perform biochemical (WB; Luminex) and immunofluorescence/confocal studies. It is also equipped with 1 electrophysiology set-up to make in vitro patch-clamp recordings. Animal model studies are carried out in agreement with the University of Rome Tor Vergata at which there is an animal experimentation enclosure.

In convention: Livia Guadalupi

Interessi di Ricerca

  • Pathogenetic mechanisms of Multiple Sclerosis (MS)-inflammatory synaptopathy
  • Identification of biomarkers of synaptopathy and molecular targets in MS
  • Impact of ‘exercise and nutrition on the processes of neuroinflammation and neurodegeneration
  • Anti-synaptotoxic properties of new drugs and drugs already on the market
  • The crosstalk between the immune system and the nervous system


  • De Vito F, Balletta S, Caioli S, Musella A, Guadalupi L, Vanni V, Fresegna D, Bassi MS, Gilio L, Sanna K, Gentile A, Bruno A, Dolcetti E, Buttari F, Pavone L, Furlan R, Finardi A, Perlas E, Hornstein E, Centonze D, Mandolesi MiR-142-3p is a Critical Modulator of TNF-mediated Neuronal Toxicity in Multiple Sclerosis. Curr Neuropharmacol. 2023 Apr 5. doi: 10.2174/1570159X21666230404103914. Epub ahead of print. PMID: 37021418.
  • De Vito F, Musella A, Fresegna D, Rizzo FR, Gentile A, Stampanoni Bassi M, Gilio L, Buttari F, Procaccini C, Colamatteo A, Bullitta S, Guadalupi L, Caioli S, Vanni V, Balletta S, Sanna K, Bruno A, Dolcetti E, Furlan R, Finardi A, Licursi V, Drulovic J, Pekmezovic T, Fusco C, Bruzzaniti S, Hornstein E, Uccelli A, Salvetti M, Matarese G, Centonze D, Mandolesi MiR-142-3p regulates synaptopathy-driven disease progression in multiple sclerosis. Neuropathol Appl Neurobiol. 2022 Feb;48(2):e12765. doi: 10.1111/nan.12765. Epub 2021 Oct 6. PMID: 34490928; PMCID: PMC9291627.

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